There are many definitions of repeated implantation failure in IVF. At present, it is generally recognized that more than 10 high-quality embryos have not been pregnant after 2-6 egg retrieval cycles.
Embryo implantation is a complex process, including three stages: adhesion, dissolution and invasion. Abnormal implantation at any stage of embryo implantation may lead to implantation failure, so RIF is a syndrome with complex etiology.
For women who fail or succeed in implantation but often miscarry, they should first go to regular hospitals to investigate the causes of recurrent abortion and take correct countermeasures according to the causes.
The factors causing RIF involve many aspects, and the quality of embryos and endometrial receptivity are the main factors affecting embryo implantation:
Embryonic chromosomal abnormality
Whether male or female, as long as chromosome abnormalities will affect embryonic development, making the embryo grow to a certain stage and no longer grow.
Abnormal internal environment of uterus
The uterus is the place where the fetus grows. Once the uterus changes, it will inevitably affect the implantation of embryos.
Endometrium is too thin
In the past, multiple curettages or abnormal menstruation will make the endometrium thin, so that the fertilized eggs cannot be normally planted on the endometrium.
Ovarian corpus luteum insufficiency
Insufficient progesterone in the body leads to low progesterone in pregnant women, which cannot provide the necessary nutrition for the fetus, and habitual abortion will occur even if the fetus can conceive normally.
Hydrosalpinx affects embryo implantation in all directions. After embryo implantation, hydrosalpinx enters the uterine cavity under pressure, which will not only affect the contact between the embryo and the intima, but also wash away the embryo and prevent embryo implantation.